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Gromada J, Bokvist K, Ding WG et al (1997) Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels

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These crystals form when uric acid levels in the blood become elevated (hyperuricaemia), leading to painful, swollen jointsmost commonly affecting the big toe, but also ankles, knees, and other joints